NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Aspiring to Improve Patients’ Lives
NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Connecting Patients with Innovation for Life
NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Committed to Addressing Unmet Medical Need
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NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Aspiring to Improve Patients’ Lives
NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Connecting Patients with Innovation for Life
NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES
Committed to Addressing Unmet Medical Need

Atopic Dermatitis

CBP-201, an anti-IL-4Ra antibody, is in clinical trial development to treat atopic dermatitis (AD) patients with moderate-to-severe AD. A Phase 2b study in this population showed CBP-201 met the primary endpoint of eczema area and severity index (EASI) percent reduction from baseline at Week 16 and were statistically superior to placebo. Clinical trials are ongoing for CBP-201 in patients with moderate-to-severe atopic dermatitis (AD) and moderate-to-severe persistent asthma with type 2 inflammation.

IBD

CBP-307, a small molecule modulator of S1P1, is currently being evaluated in a global Phase 2 clinical study in patients with ulcerative colitis. CBP-307 is not a pro-drug and does not require conversion to an active form in the human body following administration.

Pruritus

We are developing CBP-174, a peripherally acting, small molecule H3R antagonist, for oral administration to treat chronic pruritus associated with skin inflammation. CBP-174 is currently being evaluated in a Phase 1 dose-escalation study in healthy subjects. Our preclinical models have indicated that CBP-174 led to reductions in scratching in mice within the first 30 minutes of dosing, which could potentially translate to rapid reduction in pruritus in the clinic.

Many autoimmune and allergic inflammatory diseases share a common biologic origin: inappropriate activity of Th2 cells that normally play a critical role in preventing infections and cancer. Abnormal Th2 activity leads to inflammation and destruction of healthy tissue. Our expertise in Th2 biology, and our proprietary Immune Modulation Technology Platform allow us to radically reduce the time and cost of discovering novel small molecules and biologics that have best- and first-in-class potential as therapies for serious autoimmune and inflammatory diseases that have significant unmet need.