CBP-174 is a peripherally acting histamine 3 receptor (H3R) antagonist for oral administration to treat chronic pruritus associated with skin inflammation.

There are four types of histamine receptors, and most common antihistamines block the H1 receptor, which can lead to undesirable central nervous system side effects. CBP-174 was designed not to penetrate the blood brain barrier and has been well-tolerated in multiple preclinical studies.

Target Indications

Pruritus due to atopic dermatitis

Chronic inflammatory pruritus (itch) is a hallmark of atopic dermatitis (AD) and is one of the most difficult AD symptoms to manage.1 In some cases, the sense of itch may be so intense that patients scratch themselves until they bleed.1 Pruritus also has negative impacts on quality of life for patients with AD.1 Currently available anti-inflammatory agents may require many days or weeks of continuous treatment to provide relief to patients with pruritus associated with AD.1 We believe novel therapies that rapidly, safely and effectively reduce chronic pruritus will be important for improving the health and quality of life outcomes for patients with AD-associated pruritus.

Mechanism of Action

Current Development Status

The Phase 1, first-in-human study was completed and topline results were delivered in Q3’22 (more details here).

Promising Preclinical Data

In a preclinical model of histamine-induced pruritus in mice, CBP-174 at an oral dose of 0.1 mg/kg led to significant reductions in scratching. We observed that CBP-174 had a strong anti-itch effect in mice with a rapid onset of action, within the first 30 minutes of dosing. Administration of CBP-174 orally was well-tolerated with no clinical signs of toxicity in a 28-day multiple-dose study of up to 5 mg/kg in rats.

Posters & Publications

  1. Hong J, Buddenkotte J, Berger TG and Steinhoff M. Management of Itch in Atopic Dermatitis. Seminars in Cutaneous Medicine and Surgery. 2011;30(2):71-86. doi: 10.1016/j.sder.2011.05.002